Department of Statistics, University of Auckland

2002-10-17

Room GB19 (G block basement)

Spotted microarray technology is rapidly becoming a mainstay for conducting gene expression experiments. This talk will provide an overview of the topic, with a focus on the application of standard statistical techniques to the analysis of data from microarray experiments. Specifically, analysis of variance methods are used in conjunction with hypothesis testing procedures to detect genes undergoing differential expression, and techniques for limiting testing errors are investigated in both the Bayesian and frequentist settings. These analysis methods are then applied to data from Arabidopsis microarray experiments, and are shown to be successful in detecting genes exhibiting differential methylation, while providing a high level of protection against the possibility of false positive results.